Endocrine Abstracts

Background: Adrenocortical carcinoma (ACC) is a rare malignant tumor with a poor prognosis. The only curative therapy is complete surgery (R0). A 5-year local recurrence and distant metastasis rate after R0 is 80–85%. Mitotane is widely used as an adjuvant treatment in patients with a high risk of recurrence. According to the most studies, it can delay and possibly prevent a recurrence of the disease in 35–50%. However, its efficacy is controversial, as well as the o...

Introduction: Adrenocortical carcinoma (ACC) is a rare malignant tumor with heterogeneous prognosis. The median overall survival of all ACC patients is about 3-4 years. Complete surgical resection provides the only cure [Fassnacht M, et al., 2018]. In cases of advanced ACC, therapeutic options are limited. No effective second-line therapies are recommended for patients with disease progression to EDP chemotherapy scheme and Mitotane. It is essential to study alternative drugs,...

Relevance: Due to numerous causes of PA, AVS allows differentiating variant nosological forms of PA. The importance of differential diagnosis is due to the fact that surgery is reasonable only with unilateral variant of PA, while in idiopathic hyperaldosteronism surgery isn’t a method of choice.Purpose: To assess the diagnostic possibilities of using AVS against the background of endogenous stimulation of adrenocorticotropic hormone (ACTH) in the ea...

Objective: Tumor-induced osteomalacia is a rare paraneoplastic syndrome in which fibroblast growth factor 23 (FGF-23) hyperproduction by tumor causes renal phosphate wasting, severe hypophosphatemia and osteomalacia. Localization of the tumor can be a major diagnostic challenge.Material and methods: We present a clinical case concerning a 62-year old woman previously diagnosed with hypophosphatemic osteomalacia, with a slight improvement of clinical and ...